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Dosing protocols Phase 2 clinical trials used a titration schedule starting at 0.5mg weekly, escalating through 1mg, 2mg, 4mg, 8mg, and reaching maintenance doses of up to 12mg weekly over several months

But they work through entirely separate receptor systems, activating different neural pathways and producing complementary effects when combined

2 Design logic of multifunctional nanotherapies targeting the tumor microenvironment 2.1 Key tumor microenvironmental barriers and corresponding design objectives The tumor microenvironment features that shape drug delivery and therapeutic response in solid tumors can be grouped into three levels that are particularly relevant for nanomedicine design, namely the vasculature and interstitium, the extracellular matrix, and the immune compartment [29,30,31]

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