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When stratified by administration route, the mean percentage changes were: Intramuscular (IM): 307% Oral: 285% Sublingual: 199% IM administration showed the highest average B12 increase, although oral and sublingual routes also yielded substantial improvements, supporting their use as effective and less invasive alternatives

In non-CBD treated mice, hypoxia-induced HIF-1 activation was less pronounced, while the lipid peroxidation and free iron level in the hippocampus were elevated