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This structure provides a rationale for the observed low Cu I binding affinity and enhanced nucleophilicity that prevents crosstalk with the copper sensor CsoR in the same S

Interestingly, inhibition of the binding to IKK by using a peptide inhibitor reduced NF-kB activity and thereby senescence in progeroid mice (88)

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Our analysis of controlled studies with available results highlights the feasibility and benefits of various digital therapeutic and long-term care interventions (Supplementary Data 2), particularly in symptom relief and QoL improvements