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In line with these predictions, Fh1 / cells exhibited a significant overexpression of Slc7a11, a member of the cystine transporter xCT, which was functionally associated with increased uptake of cystine (Fig

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However, excessive NFE2L2 activation may also promote intracellular cysteine accumulation, which can react with sugars to form adducts that impair cell proliferation 163

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