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Upregulated genes were enriched in pathways related to T cell differentiation and activation (for example, RUNX3 , IFNG , TNFSF9 ), negative regulation of the immune response (for example, WASL , ID2 , TNFAIP3 ) and circadian regulation of gene expression (for example, RORA , PER1 , NRIP1 ) (Fig

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In some embodiments, the antioxidant or anti-apoptotic agent is Sodium Thiosulfate, Potassium Thiosulfate, HMTBa, Oltipraz, D-cysteine, D-methionine, or a combination thereof

Key significance: One of the first mitochondrial-derived peptides identified opened the field of MDP research DSIP (Delta Sleep Inducing Peptide) DSIP is a 9-amino-acid neuropeptide originally isolated from rabbit brain tissue during induced sleep