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A 2021 meta-analysis in the American Journal of Sports Medicine showed improved pain and function in rotator cuff tendinopathy patients treated with PRP versus placebo

Alzheimers Dement (N Y) 2018;4, 575-590, doi:10.1016/j.trci.2018.06.014

Understanding the limitations of this data helps set realistic expectations about long-term use

Common causes of temporary post-injection pain include: Local inflammation: The injection itself can irritate surrounding tissues Increased joint pressure: The added fluid volume temporarily stretches the joint capsule Normal healing response: Your bodys natural reaction to any needle puncture Muscle tension: Protective guarding around the injection site According to Cleveland Clinic, this reaction typically manifests as mild pain and swelling at the injection site and resolves without intervention [3]

doi: 10.1038/nn.2250