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So when the cell suddenly has a surplus, one of the ways it can soak up that excess is by ramping polyamine production

For example, while it is normal for your first few treatments to take place within the same week, usually about one day apart, your subsequent treatments will have a slower frequency

She was like, Can we go 405, whatever

Biochemistry 2009, 48, 23012303

The concern is prolonged high-dose supplementation without medical advice, or a blood test showing persistently high B12 when someone is not taking supplements