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[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Prasun P, LoPiccolo MK, Ginevic I, et al

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Importantly, KRAS-dependent NSCLC cells that were hypersensitive to LDHB/SLC7A11 inhibition (A549, H460, H2122, H838, H2009, KP) exhibited high levels of NRF2 or NRF2 score based on prior studies [57, 58], whereas the outliers (H358, H23, and Calu-1), in which LDHB KD failed to sensitize the cells to Erastin or RSL3, are characterized by low NRF2 levels