Use the 5 R's to motivate patients to consider a quit attempt
There is no right combination
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However, marketing approaches often target young people resulting in high uptake of vaping products among this age group, and the degree to which dual-users transition completely away from smoking is unclear, with most continuing to smoke at least in the short term

Robert Bradshaws unpublished advice treatise The way to weldoeing, written some time during James reign, included the story of a captured pirate in Suffolk who being redie to dy sayd that the great love he bore unto tobacko was the furst and chef occasion of his overthrow, since the importinat delight in taking that harming smoke propelled him further into drink, excess, women, and eventually theverie and manie other disordrs.Footnote 74 Iniqitie, Bradshaw concluded, shall bring all the earth to a welderness, one that could only be salvaged by good governors.Footnote 75 Bradshaw associated poor manners with a tendency to disobedience: [Question] What is the reason thinke you that somanie greatwons as well as small creatturs transgress and break the kings laws [?] [Answer] becaus they wer not brought up in good manors.Footnote 76 James A counterblaste to tobacco (1604) specifically argued that uncivil habits were a danger to the polity