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Indeed NSAIDs, by virtue of their renown anti-inflammatory and antiplatelet (especially aspirin) activities could be beneficial for both the early control of inflammation and the prevention of thromboembolism, thus theoretically limiting COVID-19 progression in a bimodal pattern
Additionally, ergosterol (ER) has been found to enhance Nrf2 activity, inhibiting molecules related to ferroptosis, such as MMP-9 and MMP-13, which strengthens the cells resistance to oxidative stress and protects chondrocytes from damage ( 4.3.2 Superoxide dismutase (SOD) and catalase (CAT) SOD and CAT are essential enzymes in the antioxidant defense system
[DOI] [PubMed] [Google Scholar] [148].Cho YS, Lee J, Lee TH, Lee EY, Lee KU, Park JY, Moon HB
J Eur Acad Dermatol Venereol 32(3):397402
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