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Therefore, even low levels of HBV-DNA positivity can potentially transmit HBV infection, making treatment essential and unavoidable for all HBV-DNA-positive individuals

Additionally, the ability of PDA to respond to environmental stimuli, such as pH changes, enables precise control over the release of the drug at the desired location [107]

However, a controversial result revealed that baicalein-mediated ferroptosis of bladder cancer cells was triggered by downregulating FTH1, accompanied by the accumulation of ROS and iron (Kong et al., 2021)

The mechanisms involved in such strategies are complex, because reduced ascorbate is highly susceptible to oxidation in aqueous solution and, moreover, it is likely to be oxidized by the ascorbate oxidase activities in the apoplast/cell wall compartments of the plant cell before it enters the cytoplasm