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However, electrons may prematurely leak from complexes I, II, and III to mediate the one-electron reduction of oxygen to O 2 , which is then dismutated to H 2 O 2 (Fig

M2 activates STAT6 and STAT3 to drive polarisation by cytokines (IL-4, IL-13, IL-10, etc.), mediates ROS-induced tissue damage, and has anti-inflammatory and anti-tumor activities [21-23]

Although we cannot rule out that the increased production of ROS in 3D culture conditions may not be observed under hypoxia, it should be noted that hypoxia itself induces ROS production in numerous cell types, including tumor cells [39]

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A different BAC water volume would change the peptide per unit