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The tandem of free radicals and methylglyoxal

Pro-inflammatory cytokines represented by IL-1, IL-6, TNF- , and IFN can activate IDO, while anti-inflammatory cytokines such as IL-4 can down-regulate the enzyme

Nat Chem Biol 9:119127 Mailloux RJ, Treberg JR (2016) Protein S-glutathionlyation links energy metabolism to redox signaling in mitochondria

Stimuli-responsive nanocarriers for drug delivery

This is very important, especially in light of the ADA position [37], which recognizes that the personalization of anti-diabetic therapyrather than a one-size-fits-all treatmentis necessary to achieve successful glycemic targets