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However, these uses are still under research, and no conclusive clinical recommendations exist for routine use

3 Oxidative stress Oxidative stress is a disbalance caused by excessive production of prooxidant substances such as ROS and RNS and/or the antioxidant systems working inefficiently ( in vivo primarily by the mitochondrial respiratory chain during aerobic metabolism ( via a reaction between nitric oxide (NO) and superoxide, and nitrosoperoxycarbonate, generated via a reaction between peroxynitrite and carbon dioxide

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Pernicious anemia , an autoimmune disease that destroys intrinsic factor production, prevents adequate B12 absorption regardless of dietary intake or oral supplementation attempts

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