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As it is essential to consider that these nanoparticles did not cause significant damage to the normal tissues of mice, above all studies demonstrated acceptable biocompatibility and safety in cell or small animal models [236,237,238,239,240]

Main histological changes of ATN are: merging and loss of tubular epithelial cells, focal dilatation of proximal tubules, partial occlusion of tubular lumens by cellular debris and multiple mitoses

This rapid metabolism, combined with poor water solubility and limited absorption in the gastrointestinal tract, leads to insufficient plasma concentrations to exert significant pharmacological effects 18,19

Post-processing of the simulated data laid out the spatial deposition trends, which were then tallied against in vitro observations