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Both endogenous and exogenous forms of vit-D are inactive and require two successive hydroxylation steps by cytochrome P450 (CYP) enzymes to form fully active vit-D

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This can also be achieved by incorporation of additional compounds, such as drugs or growth factors, to elicit various beneficial responses within the TME

The same goes for frequent gym-goers and athletes, since intense training temporarily raises oxidative stress as a normal part of recovery