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In contrast, CR-fed females not only had reduced plaques, but had reduced glial activation relative to both CR and DL-fed mice, with substantially lower pro-inflammatory gene expression, suggesting that while caloric reduction alone may attenuate plaque pathology, the reduction in plaque deposition observed in the DL-fed mice may not be mediated by glial cells

PLoS ONE 13:e0204324

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Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders

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