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Patients may exhibit symptoms such as difficulty falling asleep, disrupted sleep, trouble going back to sleep, early awakenings, and feeling tired upon waking

aureus metabolism, leading to the discovery of KL1, a host-directed compound that sensitizes persisters to antibiotic killing

3.3 Glutamate dehydrogenase (GLUD/GDH) inhibitors Glutamine is enzymatically converted to glutamate by glutaminase, and further conversion of glutamate to -KG is facilitated by GLUD through oxidative deamination (Yoo et al., 2020)