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Mammea type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell cycle alterations

In line with the "seed and soil" theory, tumour cells ("seed") preferentially grow in organs with a suitable microenvironment ("soil"), leading to a non-random distribution of metastasis among organs

Reconstitute at the same time and place

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Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, et al