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Because B12 shots are administered intramuscularly, they bypass the digestive system, allowing the body to absorb a much larger amount of B12 that would otherwise be lost during digestion

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Ewert A, Leifheit-Nestler M, Hohenfellner K, Buscher A, Kemper MJ, Oh J, Billing H, Thumfart J, Stangl G, Baur AC, Foller M, Feger M, Weber LT, Acham-Roschitz B, Arbeiter K, Tonshoff B, Zivicnjak M, Haffner D (2020) Bone and mineral metabolism in children with nephropathic cystinosis compared with other CKD entities