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Indeed, HGF protects BBB disruption after microsphere embolism-induced sustained cerebral ischemia by avoiding the inhibition of Bcl-2 (Date et al., 2006), thus decreasing apoptosis, and by reducing the expression of occludin and zonula occludens (ZO)-1, which are tight junction proteins, in cerebrovascular endothelial cells (Takeo et al., 2008)

Research involving BPC-157 has extended beyond gastrointestinal physiology into studies of connective and musculoskeletal structures, vascular biology, and cellular adaptation

For example, animal model studies have demonstrated that treatment with Xiaoyaosan for depression leads to changes in the gut microbiota that correlate with improvements in depressive symptoms