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SASP induction by senescent cancer cells can also improve tumor vascularization, a phenomenon that may be considered beneficial, as demonstrated in previous studies on PDAC cells [39]
In an in vitro study of tendon fibroblasts isolated from Achilles tendons of male Sprague-Dawley rats, Chang and colleagues reported that BPC-157 significantly accelerated the outgrowth of tendon explants and amount-dependently increased the in vitro migration of tendon fibroblasts [2]
doi: 10.1016/S1995-7645(14)60307-2
However, in the transition to memory NK cells, damaged mitochondria are removed via mitophagy-related proteins such as BNIP3(L), thereby reducing mtROS production and supporting the formation of memory NK cells (93)
14 Prager N, Bickett K, French N, Marcovici G
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