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An example of such can be observed in a study where Cre-dependent activation of Ube3a in Ube3a Stop/p+ embryonic mice restored all AS-associated motor, behavioral, and neurological deficits, whereas Ube3a reactivation in postnatal mice demonstrated diminishing efficacy with age for motor coordination rescue [183]

Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease

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