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NMN (Jin'an Yunqiao Health Management Co., Ltd., Shanghai, China.) was delivered intraperitoneally to the animals in the aged + NMN group at a dose of 500 mg/kg body weight

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While AgRP GHR KO mice showed no changes in growth or basal metabolism, both LepR GHR KO and brain GHR KO mice displayed increased weight gain over time, associated with a higher body length