First, we assessed protein expression in Be(2)-C cells treated with either MitoQ IC50, DPI IC50, vin IC50 or the double and triple drug combinations, versus control ( Supplementary Figures S3 - S6
Type II to Type I Transformation: Research suggests it can help remodel skeletal muscle fibers toward an oxidative (endurance-focused) phenotype
Additionally, AOD9604 may have effects on fatty acid oxidation in peripheral tissues, enhancing the utilization of released free fatty acids for energy production rather than allowing them to be re-esterified and stored
Figure 6 Together, proteomic and phosphoproteomic profiling highlighted cell cycle and proliferation pathways as key targets of the double and triple drug combinations ( Figures 6C, D
(PubMed) Clements M, Heffernan M, Ward M, et al