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Dysregulation in mitochondrial sheath formation can result in reduced sperm midpiece flexibility, impaired midpiece structural stability and perturbed energy production, all of which are detrimental for effective sperm motility and overall male fertility

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DOI: 10.1056/NEJMoa2502081 Davies MJ, Bajaj HS, Broholm C, Christiansen E, Fink LN, Hussein Z, et al