The rule is: use GHK-Cu in the evening and L-ascorbic acid in the morning, or substitute a stabilized ascorbic acid derivative (ascorbyl glucoside, sodium ascorbyl phosphate) that does not donate electrons as freely to copper
Sauer, R., Becker, H., Hohenberger, W., Rdel, C., Wittekind, C., Fietkau, R., et al
Manufacturing mucoadhesive formulations can also be complicated owing to their complex surface chemistries (such as thiolation or carbomer coating), which make consistent production harder than that of simpler muco-penetrating particle coatings
Synapse 3 : 4854 Kalivas PW, Duffy P
Abstract Women with endometriosis, the growth of endometrial glands and stroma outside the uterus, commonly also exhibit adenomyosis, the growth of endometrial tissues within the uterine muscle