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Overall, the treatment of in vitro granulomas generated from PBMCs isolated from T2DM subjects with 1/10 MIC for PZA (5 g/ml) and 1/10 for MIC INH (0.0125 g/ml) treatment resulted in a significant decrease in the M

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It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)

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PeerJ 12, e18227