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The primary endpoint for this study was the number of live offspring per round of confirmed mating, which was determined by the presence of a vaginal plug as described above, and the total number of live offspring for each cohort, with n = 10 animals per group

doi: 10.29261/pakvetj/2025.121 28 YuXXuJSongBZhuRLiuJLiuYFet al

Some of the PR3 SNPs are associated with higher PR3 plasma levels in healthy individuals (158)

However, BBB rupture, which has been observed in both PD patients and experimental models, encourages the entry of inflammatory mediators and oxidative agents, which raises NLRP3 activation and speeds up neuronal degradation [54]

Consequently, elevated ROS levels encourage fluid leakage, fostering the development of cystoid macular edema, which occurs in 1050% of retinitis pigmentosa patients and is a major contributor to central vision loss [293,346]