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This includes the following: Skin Lips Mouth Nose Esophagus Stomach Throat (Tongue, Soft Palate, and Tonsils) Voice Box Liver Kidney Pancreas Bladder Bone Blood Cervix Vulva Colon Penis Anus Chronic Respiratory Conditions Smoking is the principal cause of chronic obstructive pulmonary disease (COPD), a severe, progressive, and disabling condition that restricts airflow in the lungs