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It is a critical, widely documented phenomenon in the transformation of neoplastic features regarding the progression of various cancers [18]

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As a regulated form of cell death, ferroptosis can activate different downstream pathways and complex molecular effector mechanisms, leading to cell lysis in different forms and resulting in morphological changes and immune responses [10]

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found that serum copper concentrations in patients with stage 1 bipolar disorder (including depression) were significantly higher than those of patients in advanced stages (2 + 3 + 4) of bipolar disorder (including depression) (Siwek et al., 2017)