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The maintenance frequency approach offers middle ground where users completing intensive initial treatment (6-12 months daily) transition to reduced frequency (2-4 times weekly) maintaining copper supplementation at lower intensity and cost while avoiding complete discontinuation allowing some benefit decline

Because the effect is GnRH-dependent , blocking GnRH abolishes kisspeptins LH/FSH response confirming it works by engaging the bodys own hypothalamic machinery [9]

United European Gastroenterol

The fact that most of the studies included only live-born infants and did not record or observe stillbirths, spontaneous abortions, or induced abortions due to severe malformations, potentially led to underestimations of the strength of the associations between SSRIs and fetal congenital malformations