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Once inside the cell, the -glutamyl amino acid can be further metabolized to release the amino acid and 5-oxoproline, which can be converted to glutamate and used for GSH synthesis

Mitochondrial Signalling (MOTS-c) MOTS-c is a mitochondrial-derived peptide that modulates AMPK signalling and the cell's metabolic stress response

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These improvements in senescence markers and the inflammatory microenvironment underscore FOXO4-DRIs potential to rejuvenate testicular function by clearing senescent cells and mitigating their detrimental effects

Retrieved 15 July 2021