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doi: 10.1089/ars.2007.9.49 90 SatohTEnokidoYAoshimaHUchiyamaYHatanakaH

5 4) Tendon & connective-tissue pathways (GHR up-regulation) In tendon fibroblasts, BPC-157 up-regulates the growth-hormone receptor (GHR) at mRNA and protein levels and augments downstream JAK2 signaling in response to GHmechanisms consistent with tendon repair biology (in-vitro)

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It can be concluded that the 2 nd activity controller influences both diphenolase and tyrosinase activity and acts as a substrate selector, but it is not able to inhibit monophenolase activity