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First-in-human phase I, dose-escalation and -expansion study of telisotuzumab vedotin, an antibody-drug conjugate targeting c-Met, in patients with advanced solid tumors

Active malignancy is an absolute contraindication: IGF-1 is a mitogenic signal, and elevating it in the context of cancer or pre-cancer is not justified by any available benefit data

Its main mechanism of action is based on increasing the expression of BDNF (Brain-Derived Neurotrophic Factor) and its TrkB receptors in the hippocampus and prefrontal cortex, promoting synaptic plasticity, long-term potentiation (LTP), and memory consolidation (Dolotov et al., Neuroscience 2006)

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What are the most common side effects of Isotretinoin (Accutane)