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doi: 10.3389/fonc.2020.01539 Received 31 May 2020 Accepted 19 July 2020 Published 28 August 2020 Volume 10 - 2020 Edited by Bruno Sainz Jr., Autonomous University of Madrid, Spain Reviewed by Patricia Sancho, University of Zaragoza, Spain
The most commonly prescribed drug for reducing the production of uric acid is allopurinol
Murine colon cancer cells MC38 (CL-0972, Procell, China) and MC38-Luc (YC-A002-Luc-P, Ubigene, China), human colon cancer cells HCT116 (CL-0096), SW48 (CL-0513), RKO (CL-0196), SW620 (CL-0225), DLD-1 (CL-0074) and HT-29 (CL-0118) (Procell, China), human immortalized colonic epithelial cells (NCM460, H1-3701, OriCell, China), human umbilical vein endothelial cells (HUVEC, CP-H082, Procell), human liver cells (L-02, H1-2501, OriCell), and rabbit squamous carcinoma cells (VX2, BFN60700420, BLUEFBIO) were cultured in Dulbeccos Modified Eagles Medium (DMEM) (C11995500BT, Gibco, USA) containing 10% (v/v) fetal bovine serum (FBS) (10099-141, Gibco, USA)
Over time, the duration and frequency of these flares may increase, resulting in chronic gouty arthritis and subcutaneous deposits of crystals, referred to as tophi, both of which can lead to the destruction of joints and musculoskeletal disability
Most research supports continuous supplementation rather than cycling for both compounds
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