FSH: follicle-stimulating hormone, LH: luteinizing hormone, EBRT: external beam radiation therapy, SOD: superoxide dismutase, ROS: reactive oxygen species, NO: nitric oxide, MDA: malondialdehyde, Bcl-xL: B-cell lymphoma-extra-large, Bcl-2: B-cell lymphoma 2, PARP-1: poly-[ADP-ribose] polymerase 1, LDH: lactate dehydrogenase, PCNA: proliferating cell nuclear antigen, BAX: Bcl-2 associated X protein, TNF-: tumor necrosis factor-, ACP: acyl carrier protein, -NAG: N-acetyl glucosamine, -GAL: galactosidase, GnRH: gonadotropin-releasing hormone, PM: particulate matter, BPA: bisphenol A, BADGE: BPA diglycidyl ether, DBP: dibutyl phthalate, DEHP: diethyl hexyl phthalate, MBP: mono butyl phthalate, MEHP: mono ethyl hexyl phthalate, SHBG: sex-hormone-binding protein, ED: erectile dysfunction, PFAS: perfluoroalkyl substances, PFOS: perfluorooctanesulfonic acid, PCB: polychlorinated biphenyl, HPG: hypothalamicpituitarygonadal

Long-term use of either medication can lead to tolerance, meaning higher doses are needed over time for the same effect
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I hope this put your mind at ease
Supplementation is critical in managing EPI alongside enzyme therapy