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Despite the emergence of numerous treatment strategies such as chemotherapeutic agents, small molecule inhibitors, specific gene, or protein targeting so-called smart drugs, and immunotherapies that are found to be effective in the treatment of some form of cancers (e.g., childhood leukemia, human epidermal growth factor receptor 2-positive breast cancer), cancer death rate, in general, has not changed substantially (only 5% since 1950

Despite extensive preclinical evidence supporting the neuroprotective potential of phytochemicals, their clinical translation remains limited owing to poor bioavailability and restricted bloodbrain barrier transport

Light rubbing is acceptable, but intensive massage is not recommended

31,35 Several studies have investigated the genetic predisposition to disc degeneration and suggested that heritability accounts for approximately 52-74% for disc disease

Zambelli A, Biamonti G, Amato A