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This selective approach may explain why hydrogen studies consistently show benefits without the potential downsides observed with high-dose traditional antioxidants, which sometimes show null or even negative effects in clinical trials

Senescent Endothelial Cell Elimination & Vascular Ageing (Frontiers in Bioengineering, 2025/2026) p53/BCL-2/Caspase-3 Pathway Activation Selectively Clears Senescent Endothelial Cells A study published in Frontiers in Bioengineering and Biotechnology investigated the mechanism by which FOXO4-DRI induces apoptosis in senescent endothelial cells

i , Crystal violet staining of different cancer cells from indicated treatment groups (72 h)