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Monitoring Strategy Baseline (before starting): Complete pain assessment with validated tools Neurological examination Basic metabolic panel, HbA1c (if diabetic), vitamin B12, TSH INR if on warfarin Cardiovascular risk assessment Ongoing: Pain assessment every 4-8 weeks initially, then every 12 weeks INR weekly 2 weeks then monthly if on warfarin Neurological examination every 6-12 months Annual laboratory monitoring for long-term use 4

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Tapered Design

In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy

GPX4 and GSH are key regulators of ferroptosis