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Nevertheless, improving the overall cellular function can also be beneficial for patients, independent of the targeted alterations being primary or consequential

[4] The angiogenesis concern deserves specific attention because it is the most biologically plausible theoretical risk

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10.1016/s0928-4257(97)89474-0 120 SikiricP.SeiwerthS.GrabarevicZ.RucmanR.PetekM.JagicV.et al (1997a)