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In sequence terms, that Cterminal block is exactly the kind of motif that enables membrane penetration, The region: ArgArgSerGlyGlyLysArgProProProArgArgArgGlnArgArgLysLysArgGlyOH` has all the hallmarks of a CPP: High local positive charge density Arginine is the key driver the guanidinium group forms bidentate hydrogen bonds with phosphate and sulfate groups on the cell surface (heparan sulfate proteoglycans, phospholipid headgroups)

(2006) noted the antimetastatic effect of epithalon, using the peptide to slow down the development of metastases from spontaneous tumors in female mice that were otherwise prone to reproductive organ tumors [8]

TB-500 safety data is less extensive but similarly suggests good tolerability in preclinical models