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The combined effect of these drugs was similar in both the IGHV-mutated and unmutated CLL subsets

Subsequently, DP breaks cysteinyl glycine into cysteine and glycine, which are reabsorbed into the cell to engage in a novel GSH synthesis pathway (summarized in Fig

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Annu Rev Biochem

In terms of pathogenicity, distinct strains show obvious divergence in core virulence traits: for example, chromosome 7 trisomic strains present attenuated hyphal formation due to NRG1 overexpression, while euploid strains form robust hyphae with stronger tissue adhesion and invasion capabilities (Kakade et al., 2023)