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A chemical probe to directly modulate the incorporation of TRF1 into shelterin would be a valuable tool to interrogate telomere maintenance mechanisms and a potential starting point for the development of novel anti-cancer therapeutics targeting the shelterin complex

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Despite this lack of validation and an incomplete understanding of its mechanisms of action, the safety profile nevertheless remains high

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Netherlands, Department of Translational Neuroscience, The Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht and Rintveld, Center for Eating Disorders, Altrecht in Zeist: Marek K