It requires a thorough search sometimes
Two degradation pathways matter: Hydrolysis: Water cleaves peptide bonds, particularly at aspartate-proline sequences, which are among the most hydrolysis-prone linkages in peptide chemistry
However, compounds with an amino acid-based structure (i.e., peptides, proteins, peptidomimetics), including those used in therapeutic applications, have a number of serious limitations, such as conformational instability, short duration of action (short half-life), and insufficient penetration through the bloodbrain barrier (BBB) [3,4,5]
Linnebank M, Moskau S, Semmler A, Widman G, Stoffel-Wagner B, Weller M, et al
The tirzepatide with B12 guide explains the rationale