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An open-label, randomized, placebo-controlled study on the effectiveness of a novel probiotics administration protocol (ProbiotiCKD) in patients with mild renal insufficiency (stage 3a of CKD)

The improvement in lipid metabolism and immune function was further confirmed in companion publications by the same research group, which showed connections between global DNA methylation and its effect on proliferator-activated receptor alpha (PPAR) (Osorio et al., 2016)

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