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Undeniably, pleiotropic bioactive small molecules can mitigate treatment-related damage and modulate inflammation, which is crucial for organ protection

This is especially important since most medicinal plants and bioactive compounds are known to play a major role in cellular detoxifying mechanisms, especially in part activating Nrf2, the major antioxidant response element involved in the attenuation of oxidative stress and an undesired pro-inflammatory response in a disease state (Ma, 2013

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casei by PCR using a pair of primer SOD_LC2W-F71/SOD_LC2W-R97 and inserted into pKLH71 and pKLH81 (digestion by Bam HI and Bgl II) to obtain pKLH295 and pKLH303, respectively, by the ClonExpress MultiS one-step cloning kit (Vazyme, Nanjing, China)