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198 , 474.e1474.e11 (2008)

While Phase 1 study records exist, peer-reviewed large-scale safety data is lacking

This highlights the crucial role of NOX4 not only in inducing cellular oxidative stress but also in regulating iron-dependent cell death, indicating its importance in both normal physiological and pathological conditions

The data fits to rate constants of: k 1 of 204 2 s 1 , k 2 of 0.22 0.01 s 1 , a k 3 of 0.005 0.001 s 1 , and a k 4 of 0.00016 0.0001 s 1

Additionally, the table details the extent of neuroprotection, oxidative stress reduction, and anti-inflammatory effects achieved by DMF treatment in the various disease models