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CYP1A1 and Metabolism of Estrogen, Cigarette Smoke, and More Genetic variants in the CYP1A1 gene are linked to a number of different health conditions, including an increased risk for estrogen-related cancers and an increased risk for lung cancer in smokers

The concern is that the flavoring masks the harshness of tobacco smoke, making it easier for people to start smoking

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This autonomy allows the brand to pivot quickly, experiment with flavors, and tailor blends to regional palates without lengthy corporate approval chains