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Abbreviations MNPs: Micro- and Nanoplastics MPs: Microplastics NPs: Nanoplastics PS-NPs: Polystyrene Nanoparticles ROS: Reactive Oxygen Species eNOS: Endothelial Nitric Oxide Synthase NO: Nitric Oxide NAC: N-Acetylcysteine LVOT: Left Ventricular Outflow Tract NLRP3: NOD-, LRR- and Pyrin Domain-containing Protein 3 (inflammasome) NF-B: Nuclear Factor Kappa B Wnt/-catenin: Wingless/Integrated Pathway with -catenin cGAS-STING: Cyclic GMP-AMP Synthase Stimulator of Interferon Genes PAI-1: Plasminogen Activator Inhibitor-1 IIb3: Integrin IIb3 (platelet receptor) PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses References Wright SL, Kelly FJ